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Updated: Jun 20, 2025

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Hinrich Abken1

  • 1Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany.

Cancer immunology research
|July 22, 2024
PubMed
概括

瘤细胞使用增加的化来抑制免疫反应. 研究人员开发了一种Siglec-9"开关"受体,将这种抑制转化为免疫激活,增强T细胞治疗癌症.

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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