一个案例研究的意识受损导致的饮酒在一个小儿病患者服用高剂量的cefixime
概括
这份病例报告详细介绍了一名儿科患者经历了一种非典型的disufiram-like反应后,cefixime过量和酒精消费. 它强调了这种反应的潜力,即使是cefixime,强调谨慎饮酒.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 儿科 儿科 儿科
背景情况:
- 类似于迪苏尔菲拉姆的反应是某些药物的已知的不良影响,包括一些化,暴露于乙醇.
- 塞菲西姆 (Cefixime) 一般被认为与其他黄素相比,引起这些反应的风险较低.
- 这些反应通常与含有甲基thiotetrazole (MTT) 或甲基thiodioxotriazine (MTDT) 部分的头类有关.
研究的目的:
- 报告Cefixime过量服用和酒精摄入后出现非典型的dissulfiram类反应的第一个儿科病例.
- 调查cefixime诱导类似于disufiram的反应的潜力,即使没有特定的化学替代剂.
- 为了强调在服用cefixime的患者中避免饮酒的重要性.
主要方法:
- 一名14岁的女性在摄入cefixime囊和酒精后出现了昏昏欲睡和失去意识的症状.
- 医疗评估包括胃洗,毒理学测试,生命体征监测和症状治疗.
- 进行了临床药剂师评估,以确定不良反应的可能原因.
主要成果:
- 毒理学测试证实该患者体内含有cefixime和酒精.
- 尽管最初怀疑药物中毒,但由于Cefixime过量服用和酒精的结合,不典型的dissulfiram类反应被认为是可能的.
- 患者在住院治疗和支持性护理后康复.
结论:
- 这一案例代表了首次记录在案的非典型的dissulfiram-like反应的儿科患者在cefixime过量和酒精消费后.
- 它表明,即使没有MTT或MTDT环,cefixime也可能诱导二硫类反应.
- 医疗保健提供者应谨慎使用cefixime,并建议患者避免饮酒和含酒精的产品.
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