孕产妇的雄激素及其代谢物埃蒂奥科拉诺龙对鸟类产前发育的影响
Yuqi Wang1, Bernd Riedstra1, Ton Groothuis1
1University of Groningen, Groningen Institute for Evolutionary Life Sciences, 9700 AB Groningen, The Netherlands.
The Journal of experimental biology
|July 22, 2024
概括
母亲的雄激素如丸激素和安德二 (A4) 影响后代的发育. 然而,它们的代谢物埃蒂奥科拉诺龙不能复制和A4在鸟类胚胎中的作用.
科学领域:
- 生殖生物学 生殖生物学
- 发育生物学是发展生物学.
- 内分泌学 在内分泌学.
背景情况:
- 孕产妇的雄激素,包括和二 (A4),可以影响后代的表型.
- 鸟类胚胎迅速代谢这些雄激素,这引发了关于母体激素或其代谢产物是否介导发育效应的问题.
- 代谢物Etiocholanolone在胚胎发育过程中增加,并可能在调解母体效应方面发挥作用.
研究的目的:
- 调查和比较产前暴露于和A4与其代谢物埃蒂奥科拉诺龙对鸟类胚胎发育的影响.
- 为了确定etiocholanolone是否模仿其前体原体对胚胎特征的影响.
主要方法:
- 黑头海 (Larus ridibundus) 的蛋注射了,A4或etiocholanolone,假注射的蛋作为对照.
- 分析了胚胎心率,化前生物识别特征 (鼻孔长度,长度,大脑质量),白细胞与红细胞的比率 (W/R比率) 和毛囊发育.
主要成果:
- 和A4治疗增加了胚胎心率,减少了嘴巴的长度和W / R比率,无论产卵顺序如何.
- 埃提科拉诺治疗没有复制这些效应;相反,它减少了长和大脑质量.
- 埃蒂奥科拉诺的独特作用表明,它在胚胎发育过程中不能完全模仿和A4的作用.
结论:
- 胚胎对母体和A4的新陈代谢可能会导致不同的功能结果,因为代谢物etiocholananolone产生不同的效果.
- 这表明,胚胎内母性雄激素的代谢转化对于使其对后代表型的影响多样化至关重要.
- 这些发现突出了母体激素沉积和胚胎新陈代谢在塑造后代发育中的复杂相互作用.
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