青少年和成人自闭症谱系障碍中的大脑功能梯度和结构特征
Lili Ruan1,2, Guangxiang Chen3, Menglin Yao4
1Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Human brain mapping
|July 22, 2024
概括
自闭症谱系障碍 (ASD) 在青少年与成年人之间显示出明显的脑部变化. 青少年ASD涉及功能网络变化,而成年ASD显示结构变化,两者都与临床特征相关.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 大脑网络分析 脑网络分析
背景情况:
- 自闭症谱系障碍 (ASD) 研究旨在了解大脑结构-功能合和临床特征.
- 之前的研究报告了ASD中异常的大脑网络,但青少年和成年人的层次组织差异需要澄清.
研究的目的:
- 调查功能梯度,结构变化和青少年和成人自闭症的临床症状之间的关系.
- 探索大脑网络组织中的年龄相关变化及其临床相关性.
主要方法:
- 利用功能梯度和基于声素的形态学 (VBM) 分析来自176名青少年和74名患有自闭症的成年人的数据,并匹配健康对照 (HCs).
- 分析了Schaefer图谱中的1000个包裹,将其映射到Yeo的七个网络图谱中.
- 计算了梯度得分,灰质体积/密度和临床特征之间的皮尔森相关性.
主要成果:
- 与HC相比,青少年ASD在默认模式和前对对联网络中显示了压缩的功能梯度.
- 成年ASD在腹部注意力网络中表现出渐变压缩,在边缘网络中灰色密度下降.
- 功能梯度参数与青少年的临床特征相关,而VBM参数在成人中显示出相关性.
结论:
- 青少年ASD病理生理学主要涉及功能性大脑网络的改变.
- 成年ASD病理生理学与大脑结构变化 (灰色密度/体积) 更相关.
- 这些结构功能变化与临床特征有显著的相关性,为ASD病理生理学提供了新的见解.
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