SARS-CoV-2 感染使患者具有与 Staphylococcus aureus 共同感染的倾向
Ashira Lubkin1, Lucie Bernard-Raichon1,2, Ashley L DuMont1
1Department of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
mBio
|July 22, 2024
概括
严重的COVID-19 (冠状病毒疾病2019) 可能导致危险的金黄色葡萄球菌共感染. SARS-CoV-2 (严重急性呼吸道综合征冠状病毒2) 感染增加了对S. aureus的易感性,使患者和小鼠模型的结果恶化.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 病毒学 病毒学
背景情况:
- 严重的COVID-19与细菌和真菌共感染有关.
- 在COVID-19患者中,黄金葡萄球菌菌血症增加了死亡率.
- 了解SARS-CoV-2和S. aureus之间的相互作用至关重要.
研究的目的:
- 调查SARS-CoV-2阳性患者中S. aureus共感染的临床结果.
- 为了确定SARS-CoV-2是否影响S. aureus的毒性或遗传特征.
- 探索SARS-CoV-2对宿主易受S. aureus超级感染的影响.
主要方法:
- 从SARS-CoV-2+和SARS-CoV-2患者中收集的金黄色细菌分离物.
- 进行了全基因组测序和S. aureus分离体的表型特征.
- 开发并利用一种小鼠共感染模型来研究SARS-CoV-2和S. aureus的相互作用.
主要成果:
- 黄金菌的分离体显示出广泛的遗传学多样性,与SARS-CoV-2状态无关.
- 两组之间没有观察到黄金色细菌毒性特征的显著差异,除了SARS-CoV-2+分离体中低细胞毒性的趋势.
- 与SARS-CoV-2和S. aureus共感染的患者的死亡率更高,无论S. aureus细胞毒性如何.
- 感染SARS-CoV-2使小鼠更容易受到随后的S. aureus超级感染,特别是具有低细胞毒性的菌株.
结论:
- 感染SARS-CoV-2可以直接增加宿主对S. aureus共感染的易感性.
- 同感染的严重程度受到宿主的SARS-CoV-2状态和S. aureus的内在毒性的影响.
- 这些发现凸显了共感染期间病毒和细菌病原体之间的复杂相互作用.
相关概念视频
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.1K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.1K
01:26Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K
01:20Infection
7.8K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.8K
01:22Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
01:25Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K