药物负担和抗胆固醇药物的使用与肝硬化患者的明显HE有关
Jonathan A Montrose1, Archita Desai2, Lauren Nephew2
1Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hepatology communications
|July 22, 2024
概括
高剂量药物负担和抗胆固醇药物的使用增加了肝硬化和肝脏脑病变 (HE) 患者住院的风险. 减少这些类型的药物可能有利于患有HE病史的患者.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床药理学 临床药理学
- 老年病的医生 老年病的医生
背景情况:
- 多种药物和抗胆固醇药物与老年人的认知能力下降有关.
- 虽然一些药物与肝脏脑病变 (HE) 有关,但药物负担和抗胆固醇药对HE的联合影响尚未研究.
- 这项研究调查了肝硬化患者的药物负担,抗胆固醇药物的使用和与肝硬化相关的住院治疗之间的关系.
研究的目的:
- 检查药物负担和抗胆固醇药物的使用与肝硬化患者的HE相关住院病人的关联.
- 根据高等教育的历史来确定这些协会是否有所不同.
主要方法:
- 对1039名年龄在18-80岁的肝硬化患者进行了回顾性队列研究.
- 收集了慢性药物计数 (药物负担) 和抗胆固醇药物的使用数据.
- 评估的主要结果是HE相关的住院治疗,平均随访时间为840天.
主要成果:
- 增加的药物负担与较高的HE相关住院率显著相关 (HR:1.07,95% CI:1.03-1.11).
- 抗胆固醇药物暴露也独立地与HE相关住院病例的增加有关 (HR: 1.71,95% CI: 1.11-2.63).
- 这两种关联在患有HE病史的患者中都是显著的,但在没有这种病史的患者中并非如此.
结论:
- 药物负担和抗胆固醇药物的使用是肝硬化患者与肝硬化相关的住院治疗的重要风险因素,特别是那些以前患有肝硬化患者.
- 减少抗胆固醇药物的使用和整体药物负担的策略需要对这一群体的潜在临床益处进行调查.
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