红细胞作为治疗应用的药物载体的工程
Baoshuo Jia1, Yujie Shi1, Yuling Yan1
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, P. R. China.
Advanced biology
|July 22, 2024
概括
红细胞 (红红细胞) 由于其生物相容性和较长的循环时间,显示出作为药物输送载体的前景. 本综述探讨了基于红细胞的系统,用于提供各种治疗药物,增强药物稳定性,并使向治疗成为可能.
科学领域:
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
- 纳米技术 纳米技术
背景情况:
- 红细胞 (红细胞) 具有药物输送的有利特征,包括生物相容性,生物降解性和延长循环半衰期.
- 传统的药物输送系统经常面临稳定性,向性和免疫反应方面的挑战.
研究的目的:
- 提供红细胞作为药物输送载体的全面审查.
- 阐明最近利用红细胞提供各种治疗剂的进展.
- 检查基于红细胞的药物输送系统的生物医学应用.
主要方法:
- 对红细胞内药物封装的内部和表面加载策略的系统讨论.
- 对红细胞膜伪装的纳米载体进行审查,以提高生物相容性和有针对性的输送.
- 分析当前技术及其优缺点.
主要成果:
- 红细胞可以封装小分子,核酸,抗体,蛋白质酶和纳米粒子.
- 内部和表面加载方法在药物稳定性和释放动力学方面具有明显的优势.
- 红细胞膜伪装的纳米载体增强了纳米粒子的生物相容性,并使向药物输送成为可能.
结论:
- 基于红细胞的药物输送系统为各种治疗应用提供了多功能平台,包括癌症,糖尿病,血栓形成和免疫治疗.
- 对红细胞载荷药物输送的进一步研究具有促进治疗干预的巨大潜力.
- 优化装载策略和载体设计对于最大限度地提高治疗疗效至关重要.
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