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对于心力衰竭治疗的CORISMA机械循环支持 (CMCS) 系统的早期开发

Gretel Monreal¹, Steven C Koenig^2,3, James F Kelley⁴

¹Department of Cardiovascular and Thoracic Surgery, University of Louisville, 302 E. Muhammad Ali Blvd, Room 411, Louisville, KY, 40202, USA. gretel.monreal@louisville.edu.

Cardiovascular engineering and technology

|July 22, 2024

概括

科里斯马系统正在为心力衰竭 (HF) 患者开发一个紧的机械循环支持系统 (CMCS). 早期测试显示原型符合性能指标,证明了这个创新的,完全可植入的设备的概念验证.

科学领域:

生物医学工程生物医学工程
心血管器械心血管器械
医疗技术医疗技术医学技术

背景情况:

心力衰竭 (HF) 是一个重大的治疗挑战,特别是在保留喷射分数 (HFpEF) 的患者中.
现有的机械循环支持 (MCS) 系统通常涉及侵入性手术和外部驱动线的潜在并发症.
需要耐用,不那么侵入性,并且完全可植入的MCS解决方案.

研究的目的:

介绍 CoRISMA 机械循环支持 (MCS) 系统原型的早期工程开发和测试.
评估用于心力衰竭患者的紧,完全可植入的左心房 (LA) 到大动脉 (Ao) 轴流的可行性.
评估这种卸载策略对HFpEF患者的潜力.

主要方法:

计算流体动力学 (CFD) 建模被用于评估两个螺旋和扩散器设计的流量和剪切特性.
开发了定制的测试装置,用于反复改进CFD模型和实验验证.
原型在静态和动态模拟流量循环中进行了测试,模拟了心力衰竭条件.

主要成果:

在CFD预测的高流量 (4.56-4.82L/分钟在100mmHg) 与螺旋2显示更高的效率.
实验测试证实原型符合性能指标,在70-76 mmHg压力下产生4.0-4.5 L/min流量.
动态模拟循环测试证明了系统在模拟的HF条件下恢复血液动力学的能力.

结论:

科里斯马原型的早期工程设计和性能证明了概念验证.
确定了下一个设计代的关键工程规范,挑战和解决方案.
未来的发展包括将无线能量传输纳入完全植入式系统,消除驱动电路的并发症.

关键词:

计算流体动力学计算流体动力学心脏衰竭是因为心脏衰竭.驱动器驱动器是一个驱动器.机械循环支持机械循环支持假的循环循环循环循环.

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