牛群感染Mycobacterium avium亚种的便微生物多样性. 结核病:可能是生产状况的影响
Wisal A Elmagzoub1,2, Sanaa M Idris1,3, Marwa H E Elnaiem4
1Department of Animal Health and Safety of Animal Products, Institute for Studies and Promotion of Animal Exports, University of Khartoum, Shambat, 13314, Khartoum North, Sudan.
World journal of microbiology & biotechnology
|July 22, 2024
概括
这种细菌属于Mycobacterium avium亚种. 牛中的甲状腺结核病 (MAP) 感染会改变肠道微生物群,随着MAP阳性增加,其丰富性会下降. 生产状况也显著影响便的微生物组成.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物健康 动物健康
- 肠道微生物组研究研究
背景情况:
- 这种细菌属于Mycobacterium avium亚种. 帕拉结核病 (MAP) 在反动物中引起约翰氏病 (PTB),并具有潜在的动物传染性影响.
- 对MAP对肠道微生物群的影响仍然不完全理解,缺乏确的数据.
研究的目的:
- 调查MAP对自然感染PTB的牛便微生物群的影响.
- 根据MAP阳性和动物生产状态来比较微生物含量.
主要方法:
- 长度研究超过10个月在一个乳牛群的临床PTB病例.
- 通过ELISA和分子测定 (PCR,RPA) 在血清,牛奶和便中评估MAP感染.
- 使用16S rDNA元基因组学与牛津纳米孔测序分析的便样本.
主要成果:
- 所有动物通过至少一种方法对MAP呈阳性;两个动物在便中始终呈MAPDNA阴性.
- 坚果虫和细菌虫是占主导地位的科系; 螺虫,科科科科和科科科科家族是丰富的.
- 便微生物组的丰富性和均性随着MAP阳性率的提高而下降.
- 在干牛和公牛之间观察到微生物组成的显著差异,具有明显的家族和属的丰度.
结论:
- 牛便微生物群受到MAP感染状况和生产状况 (干牛与公牛) 的影响.
- 增加MAP脱落与便微生物组合的变化相关.
- 需要进一步的研究,以了解疾病控制和感染进展的影响.
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