S-Nitroso-1-Adamantanethiol浸体外电路的抗血栓和抗微生物潜力
Orsolya Lautner-Csorba1, Roopa Gorur2, Terry Major1
1From the Department of Surgery, University of Michigan, Ann Arbor, Michigan.
概括
一种新型的氧化 (NO) 供体,SNAT,被用来创建用于体外电路 (ECC) 的NO发射聚合物表面. 这种iSNAT技术在体内显著减少了血栓形成和细菌感染.
科学领域:
- 生物材料科学 生物材料科学
- 医疗器械 医疗器械
- 聚合物化学 聚合物化学
背景情况:
- 身体外电路 (ECC) 容易形成血栓和细菌感染,需要提高生物相容性.
- 氧化 (NO) 在预防血栓形成和抑制细菌生长方面发挥着至关重要的作用.
- 为长期的医疗应用开发有效的无释放材料仍然是一个挑战.
研究的目的:
- 为了合成和表征一种新的氧化 (NO) 供体,S-nitroso-1-adamantanethiol (SNAT).
- 为ECCs使用SNAT浸的聚乙烯 (PVC) 管道 (iSNAT) 开发一种不排放NO的聚合物表面.
- 评估iSNAT在预防血栓形成和细菌感染方面的体外和体内性能.
主要方法:
- 合成和SNAT的特征,一个脂性NO的捐赠者.
- 用SNAT浸PVC管道,以保持机械性能.
- 在实验室中评估持续的NO释放和稳定性随着时间的推移和绝育后.
- 在子模型中进行体内评估,以评估血栓形成和微生物生物膜抑制.
主要成果:
- 用SNAT浸的PVC管道 (iSNAT) 显示持续NO释放长达42天,与内皮水平相比.
- 在 -20°C保存1年后,NO的释放保持稳定,并且与常见的灭菌方法相容.
- 在体内研究显示,与对照组相比,iSNAT ECC中的血栓形成显著减少.
- iSNAT显示微生物生物膜形成的实质性抑制,表明双重功能.
结论:
- SNAT是一个有前途的NO捐赠者,用于创建先进的NO排放聚合物表面.
- iSNAT技术有效地减轻了ECC中的血栓形成和细菌感染.
- iSNAT为提高生物相容性和减少长期ECC应用中的并发症提供了潜在的解决方案.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
663
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
663
Antianginal Drugs: Nitrates and β-Blockers
567
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
567
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K


