产前大麻使用和孕产妇怀孕结果
Kelly C Young-Wolff1,2, Sara R Adams1, Stacey E Alexeeff1
1Division of Research, Kaiser Permanente Northern California, Oakland.
JAMA internal medicine
|July 22, 2024
概括
产前大麻使用与妊娠高血压,妊娠前,异常体重增加和胎盘断裂的风险增加有关. 需要进一步的研究来探索大麻使用特征如何影响这些孕产妇健康结果.
科学领域:
- 生殖健康 生殖健康
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 公共卫生 公共卫生
背景情况:
- 虽然研究了宫内大麻暴露的胎儿和新生儿结局,但怀孕期间对母亲健康的影响仍然不太了解.
- 评估产前大麻使用与不良孕妇健康结果之间的关联对于全面的产前护理至关重要.
研究的目的:
- 调查产前大麻使用与怀孕期间各种母亲健康结果之间的关系.
主要方法:
- 一项基于人口的回顾性队列研究分析了北加州 (2011-2019) 的怀孕情况.
- 产前大麻使用是通过自我报告或毒理学查来确定的.
- 结果包括妊娠高血压,妊娠前,妊娠糖尿病,异常体重增加和胎盘并发症,使用修改的波桑回归分析.
主要成果:
- 产前大麻使用 (6.3%的怀孕) 与妊娠高血压 (aRR,1.17),孕前 (aRR,1.08),超出指南的体重增加 (aRRs,1.05-1.09) 和胎盘断裂 (aRR,1.19) 的风险增加有关.
- 关联保持一致,无论大麻使用是通过自我报告或毒理学来定义的.
- 大麻使用的频率与特定的母亲结果有不同的关联.
结论:
- 产前大麻使用与怀孕期间的几个不良孕妇健康结果有关.
- 需要进一步的研究来阐明大麻使用剂量,模式和时间等因素如何影响这些关联.
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