在超声波上测量视神经外皮:巨细胞动脉炎的新型诊断测试
Hussein Baalbaki1, David Dubé1, Carolyn Ross1
1Vasculitis Clinic, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada.
ACR open rheumatology
|July 22, 2024
概括
巨细胞动脉炎 (GCA) 患者在超声波上显示视神经外直径 (ONSD) 增加. 这种非侵入性的视神经超声波可能有助于在床边诊断GCA.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 巨细胞动脉炎 (GCA) 是一种全身性血管炎.
- 在MRI上视神经增强是GCA中已知的发现.
- 在GCA诊断中,超声波对视神经外直径 (ONSD) 的实用性尚未被探索.
研究的目的:
- 调查超声波测量ONSD是否可以帮助诊断活跃的,新出现的GCA.
- 评估视神经超声波作为潜在的GCA的治疗诊断工具.
主要方法:
- 一项诊断准确性研究,涉及30名疑似GCA的患者.
- 视神经超声波进行测量ONSD和视神经直径 (OND).
- 对患者进行了6个月的临床GCA确认跟踪;多变量回归调整为年龄和性别.
主要成果:
- 九名参与者被诊断出患有GCA.
- 与非GCA患者 (4.02毫米) 相比,GCA患者 (5.98毫米) 的平均ONSD显著更大.
- 在GCA诊断和OND之间没有发现显著的关联.
结论:
- 患有GCA的患者在超声波上表现出明显更大的ONSD.
- 视神经超声波显示承诺作为一个快速的,非侵入性的床边测试GCA.
- 需要进一步的大型前性研究来验证这些发现,并探索ONSD作为疾病活动生物标志物.
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