瘦素在生殖和高血压在怀孕期间
Harbindarjeet Singh1, Fayez A Almabhouh2, Hisham S Ibrahim Alshaikhli3
1Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sg Buloh, Selangor, Malaysia.
Reproduction, fertility, and development
|July 22, 2024
概括
瘦素是一种调节能量平衡的激素,可能会导致怀孕期间的高血压疾病. 研究表明,瘦素注射在动物模型中增加了血压和蛋白尿,这表明它可能在妊娠前的发病过程中起作用.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 心血管生理学心血管生理学
背景情况:
- 素对能量平衡,免疫和生殖系统至关重要.
- 在肥胖和妊娠高血压疾病中观察到较高的丁水平.
- 莱普在妊娠并发症中的确切作用需要进一步阐明.
研究的目的:
- 审查关于叶黄素在青春期,怀孕和高血压疾病中的作用的文献.
- 探索潜在的机制,将瘦素与妊娠中血压升高和蛋白尿症联系起来.
- 调查马里诺布法根因和氧化应激在莱普丁诱导的高血压疾病中的作用.
主要方法:
- 关于瘦素,怀孕和高血压疾病的研究的文献综述.
- 在怀孕期间对动物模型注射勒丁的实验数据的分析.
- 检查了涉及氧化应激和海洋菌的拟议途径.
主要成果:
- 莱普已经在生理功能中发挥了作用.
- 在动物模型中,丁的使用诱导了内皮活化,高血压和蛋白尿.
- 在孕期高血压疾病的妇女中,注意到平素度升高.
结论:
- 据假设,素在孕前的发病过程中起着作用,特别是在超重/肥胖个体中.
- 氧化应激可能是叶丁诱导的内皮功能障碍,高血压和蛋白尿症的重要因素.
- 提出了一个概念框架,用于怀孕期间瘦素的影响.
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