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相关概念视频

DNA Packaging00:58

DNA Packaging

Overview
DNA Packaging00:58

DNA Packaging

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Nucleosome Remodeling02:54

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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相关实验视频

Updated: May 8, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
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可编程表面修改的IcosahedralDNA框架的调节细胞内化行为

Kui Huang1, Qiulan Yang1, Min Bao1

  • 1Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Journal of the American Chemical Society
|July 22, 2024
PubMed
概括

在DNA纳米结构的表面修改显著影响它们的细胞吸收. 了解配体类型,价值和模式是使用这些纳米载体有效的向基因和药物输送的关键.

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科学领域:

  • 生物材料科学
  • 纳米技术
  • 细胞生物学

背景情况:

  • 纳米车辆的表面修饰可以改善细胞内化以提供向.
  • 像连接体识别,价值和模式等参数影响纳米结构内细胞,特别是DNA纳米结构.

研究的目的:

  • 系统地研究表面修饰参数如何影响DNA纳米结构的细胞内化效率.
  • 阐明修改后DNA纳米结构的内细胞路径和内化后命运.

主要方法:

  • 设计和编程一个具有三种不同的连接体类型的双面DNA框架.
  • 在纳米结构表面上具有多样化的配体价值和空间分布.
  • 分析了细胞内化效率,内细胞通路和细胞内命运.

主要成果:

  • 证明了连接体类型,价值和空间布局显著影响纳米结构的内部化.
  • 确定了与不同表面修饰相关的特定内细胞路径.
  • 为DNA纳米结构的内化后行为提供了洞察力.

结论:

  • 这项研究深入了解了DNA纳米结构的表面修饰和细胞进入机制之间的关系.
  • 为设计针对细胞传递应用的优化DNA框架纳米结构提供了关键的见解.