孕期的身体活动会以特定年龄的方式改变后代大脑的APP处理
A Mohammad1, G N Ruegsegger2, T D Olver3
1Department of Health Sciences, Brock University, St Catharines, ON, Canada.
概括
母亲运动通过改变粉样蛋白前体蛋白 (APP) 处理来增强后代的大脑发育. 产前运动增加了青少年后代的成熟神经元标记物和可溶性APPα.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 分子生物学分子生物学
背景情况:
- 母亲的运动对后代的神经发育有积极的影响.
- 粉样蛋白前体蛋白 (APP) 处理对于神经发生和突触可塑性至关重要.
- APP裂变产品影响神经前体细胞的增殖和网络的发展.
研究的目的:
- 调查母亲运动和饮食对后代APP处理的影响.
- 为了确定产前运动暴露如何影响神经发育标志物.
- 为了区分母亲和后代的运动对大脑发育的影响.
主要方法:
- 雌性Wistar大鼠被食正常或西方饮食,并在怀孕期间被分配到久坐或自愿的车轮运行条件.
- 后代在6周和18周时被评估.
- 在前额叶皮层组织中测量了神经元核蛋白,可溶性APPα,可溶性APPβ和来自大脑的神经营养因子 (BDNF) 的水平.
主要成果:
- 在子宫内,母亲的运动与增加的神经核蛋白和可溶性APPα有关,并在6周大的后代前额皮质中减少可溶性APPβ.
- 运动母的后代在6周后显示出更高的成熟/亲脑衍生神经营养因子比率.
- 在6周观察到的差异是母亲的影响;在18周的差异是由于后代自己的运动状态.
结论:
- 在怀孕期间母亲的运动会影响后代的APP处理和神经元在早期发育中的成熟.
- 可溶性APPα可能在与母体运动相关的神经元成熟度的增强中发挥作用.
- 后代自己的运动习惯是成年期神经发育变化的主要驱动因素,与母亲的影响不同.
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