在更年期妇女的随机试验中,热和睡眠障碍
Mingzhuo Pei1, Carolyn J Gibson2, Michael Schembri3
1Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ.
American journal of obstetrics and gynecology
|July 22, 2024
概括
热经常扰乱更年期妇女的睡眠. 虽然与安慰剂相比,持续的酸甘 (NTG) 治疗没有改善睡眠质量,但减少热与更好的睡眠结果有关.
科学领域:
- 生殖医学 生殖医学
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 热影响高达80%的西方更年期妇女,经常导致睡眠障碍.
- 关于热在睡眠障碍和治疗诱导的睡眠改善中的特定作用的前性数据有限.
研究的目的:
- 评估持续的透皮尼特甘 (NTG) 治疗对经更年期和更年期后妇女经常出现热的睡眠质量的影响.
- 在这个人群中调查热和睡眠障碍之间的关联.
主要方法:
- 一个为期12周的随机,双盲,安慰剂对照试验,涉及141名患有热的女性.
- 通过验证的日记和问卷来评估睡眠质量 (匹兹堡睡眠质量指数) 和睡眠中断 (入睡后的清醒).
- 混合线性模型分析了睡眠结果的变化及其与夜间热频率的关联.
主要成果:
- 热是夜间醒来的主要原因 (62.6%的参与者).
- 无论是NTG和安慰剂组,都显示了夜间热的减少,睡眠开始后的清醒减少,并且改善了匹兹堡睡眠质量指数的得分.
- 在NTG和安慰剂组之间没有观察到睡眠结果改善的显著差异.
结论:
- 连续通过皮肤进行的NTG疗法在绝经妇女中没有比安慰剂更大改善睡眠质量.
- 在综合研究样本中,夜间热的较大减少与改善睡眠质量和减少睡眠中断相关.
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