加利福尼亚州消防员的后代出生缺陷,2007-2019年
Florencia Anunziata1, Madison Chapman1, Erin Delker1
1Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Preventive medicine
|July 22, 2024
概括
父亲接触消防并没有与后代出生缺陷风险的增加有关. 关于母亲对消防暴露的研究是有限的,未来的研究应该集中在职业暴露矩阵上,以减少错误分类.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 职业健康 职业健康 职业健康
背景情况:
- 有限的研究存在于与父母的消防接触相关的先天缺陷.
- 了解消防员的职业危险对于生殖健康结果至关重要.
研究的目的:
- 调查父母 (母亲和父亲) 在孕期期间职业接触消防和后代出生缺陷风险之间的关联.
主要方法:
- 利用加利福尼亚州出生证明数据 (2007-2019) 与住院记录相关.
- 在孕期期间,父母的职业被分类为消防或非消防.
- 分析了使用ICD代码和估计的调整几率比率的出生缺陷患病率.
主要成果:
- 与非消防员相比,父亲为消防员的后代的血液循环缺陷,口腔裂和呼吸系统缺陷的几率较低.
- 由于数据有限,母亲灭火和出生缺陷之间的关联是不准确的.
- 使用警察作为参考组的敏感性分析减弱了调查结果.
结论:
- 父亲的消防暴露可能与后代出生缺陷的可能性相似或略低.
- 关于母亲接触消防和出生缺陷风险的数据是不够的.
- 未来的研究应该使用职业暴露矩阵来改善暴露评估并减少错误分类.
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