童年神经变异特征,炎症和青春期慢性致残疲劳:一个纵向病例对照研究
Lisa Quadt1, Jenny Csecs2, Rod Bond3
1Department of Clinical Neuroscience, Brighton and Sussex Medical School, Brighton, UK l.quadt@bsms.ac.uk.
BMJ open
|July 22, 2024
概括
儿童的神经分歧特征,包括自闭症和ADHD,显著增加了青春期患慢性致残疲劳的风险. 这种联系是由炎症,特别是IL-6水平介导的,强调了早期干预的必要性.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 免疫学 免疫学 免疫学
背景情况:
- 儿童时代的神经分离特征,如自闭症和注意力缺陷多动障碍 (ADHD) 越来越被认可.
- 慢性致残疲劳是青春期的重大健康问题.
- 早期神经发育差异与晚期疲劳之间的潜在联系尚未完全阐明.
研究的目的:
- 调查炎症过程是否调解了童年神经分离特征和青春期慢性致残疲劳的发展之间的关系.
- 评估青少年慢性致残疲劳的风险,这些青少年有童年发现的神经分离特征的病史.
- 检查介质素-6 (IL-6) 作为潜在的炎症调解剂的作用.
主要方法:
- 一个纵向病例控制研究,使用来自阿文长度研究父母和儿童 (ALSPAC) 队列的数据.
- 分析了8115名和8036名7岁和9岁儿童的数据,其中4563名18岁完成了测量.
- 二元逻辑回归和调解分析被用来评估神经分离特征,IL-6水平和慢性致残疲劳之间的关联,控制抑郁症状.
主要成果:
- 在7岁和9岁时对ADHD或自闭症特征呈阳性查的儿童,在18岁时患慢性致残疲劳的风险大约是两倍.
- 9岁时IL-6水平升高与18岁时慢性致残疲劳风险增加显著相关.
- 发现炎症,特别是IL-6,调解了童年神经分离特征和青少年慢性致残疲劳之间的关系.
结论:
- 儿童的神经分离特征与青春期患慢性致残疲劳的风险大大增加.
- 由IL-6水平表明的炎症过程似乎在将神经分离特征与疲劳联系起来方面发挥着至关重要的作用.
- 建议进行跨诊断查和早期支持策略,以减轻这种风险.
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