人类诺罗病毒的附着因子和附着受体
Xiangjun Zhan1, Qianqian Li2, Peng Tian3
1Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Food microbiology
|July 22, 2024
概括
人类诺病毒 (HuNoVs) 引起广泛的胃肠炎. 本综述探讨了超出血基组抗原 (HBGAs) 的食物和微生物组附着因子,这对于理解传播和控制至关重要.
科学领域:
- 病毒学 病毒学
- 胃肠病学 胃肠病学
- 食品安全 食品安全
背景情况:
- 人类诺病毒 (HuNoVs) 是全球急性胃肠炎的主要原因.
- 基因组抗原 (HBGAs) 是已知的细胞受体,但一些HuNoV基因型缺乏HBGA结合,表明其他因素参与其中.
- 和生菜等食物是HuNoVs的重要传播媒介.
研究的目的:
- 审查和描述人类,食物和微生物群中HuNoVs的潜在附着因子和受体.
- 突出非HBGA附着因子在HuNoV传播和潜在的抑制策略中的作用.
- 强调了解这些因素对于控制HuNoV在食物链中的传播的重要性.
主要方法:
- 对识别和分析HuNoV附着因子的研究进行文献综述.
- 分析食物和微生物群来源的已识别的依恋因子.
- 综合目前关于超越HBGAs的HuNoV受体相互作用的知识.
主要成果:
- 在食品和微生物组中已经确定了几种与HBGAs不同的附着因子.
- 这些因素可以影响病毒与宿主细胞的结合,这表明病毒在传播中的作用.
- 胡诺病毒基因型的多样性需要探索多个受体和附着途径.
结论:
- 除了HBGAs之外的附着因子对于理解HuNoV感染途径至关重要.
- 在食品环境中描述这些因素对于制定有效的控制措施至关重要.
- 对来自食物的依恋因子的进一步研究可以导致新的策略来预防诺罗病毒爆发.
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