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Updated: Jun 20, 2025

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
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Published on: February 16, 2017

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mtDNA释放促进了cGAS-STING的激活,并加速了肌肉细胞的衰老

Ying Li1, Jie Cui1, Lei Liu1

  • 1School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China.

Cell death & disease
|July 22, 2024
PubMed
概括

衰老肌肉中的细胞衰老涉及天生的免疫信号. 这项研究揭示了线粒体DNA释放和VDAC1寡合化激活cGAS-STING,在Zmpste24-/-小鼠中驱动衰老.

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