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Updated: Jun 20, 2025

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在高度卵巢癌中,Onvansertib治疗克服了olaparib耐药性

Michela Chiappa1, Alessandra Decio2, Luca Guarrera3

  • 1Laboratory of Preclinical Gynecological Oncology, Experimental Oncology Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Cell death & disease
|July 22, 2024
PubMed
概括

将波罗样酶1 (PLK1) 抑制剂onvansertib与多基酸聚合酶抑制剂 (PARPi) olaparib结合起来,有望在卵巢癌中克服olaparib耐药性. 这种组合有效地抑制瘤生长,并在临床前模型中增加存活率.

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