较高的中心日间温度幅度与人类更大的代谢物节律性有关
Daniel P Windred1,2, Clare Anderson3,4, Katherine J Jeppe3,5
1Flinders Health and Medical Research Institute (Sleep Health), Flinders University, Bedford Park, SA, Australia. daniel.windred@flinders.edu.au.
Scientific reports
|July 22, 2024
概括
较强的核心体温节奏表明人类的昼夜系统更有组织. 这表明体温节奏可以揭示中央昼夜钟的稳定性.
科学领域:
- 时间生物学 时间生物学
- 代谢学 代谢学 代谢学
- 人体生理学 人体生理学
背景情况:
- 强大的昼夜节律对健康至关重要.
- 中央昼夜时钟调节体温节奏,它组织动物的外周节奏.
- 人体温度节奏与外围昼夜组织之间的关系尚不清楚.
研究的目的:
- 调查核心体温振幅和节律性是否与人体血代谢物的昼夜节律的组织相关.
- 为了确定一个更强的中央昼夜时钟,温度节奏表明,与更好的外围昼夜组织有关.
主要方法:
- 评估了929种血代谢物的核心体温幅度和节律性.
- 在23名健康个体中使用了40小时的持续例行程序.
- 对可以掩盖内生节律的行为和环境因素进行控制.
主要成果:
- 较高的核心体温幅度与表现为昼夜节律的代谢物数量较多有关 (R2=0.37,p=0.009).
- 增加的核心体温幅度与代谢物节律周期的变化减少相关 (R2=0.47,p=0.002).
- 这些发现表明,温度节律强度与代谢物节律组织之间存在联系.
结论:
- 人类中强大的中央昼夜钟与昼夜代谢物节律的更好组织有关.
- 代谢器节律可以作为中央昼夜时钟强度的有价值指标.
- 这项研究提供了对人类昼夜系统组织及其与核心体温的关系的见解.
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