血管压素和慢性高血压怀孕中的心血管自主调整
Mirjana Jovanović1, Bojana Stevanović2, Vladislav Pajović3
1Department of Pathophysiology, University of Belgrade Faculty of Medicine, Belgrade, RS, Serbia.
概括
在老鼠中,慢性高血压怀孕涉及改变的血管压素 (VP) 水平和基因表达. 尽管血压正常化,心血管脆弱性仍然存在,由阴道机制补偿.
科学领域:
- 心血管生理学心血管生理学
- 神经内分泌学神经内分泌学
- 生殖生物学 生殖生物学
背景情况:
- 慢性高血压怀孕 (CHP) 是一个越来越严重的健康问题,其病因不明确.
- 血管压素 (VP) 是一种神经内分泌和自主调节剂,与高血压的发展有关.
- 了解电力发电中的VP系统变化对于识别潜在机制至关重要.
研究的目的:
- 在CHP期间量化VP及其受体 (V1aR,V1bR) 的基因表达在准腹腔核 (PVN) 和上视核 (SON) 中.
- 为了评估血VP水平和自主心血管适应在CHP的老鼠模型.
- 调查怀孕期间VP系统变化和心血管变异性之间的关系.
主要方法:
- 实验使用怀孕期间自发高血压大鼠 (SHRs) 和正常血压的Wistar大鼠 (WRs).
- 血液动力学参数使用放射测距仪连续记录.
- 用RT-qPCR分析基因表达 (VP,V1aR,V1bR);用ELISA分析血VP;用光谱分析和序列方法分析自主功能.
主要成果:
- 与WR相比,非怀孕的SHR在PVN和SON中显示出更高的VP,V1aR和V1bR基因表达.
- 怀孕在SHR (SON下降) 和WR (PVN/SON增加) 中不同地改变了VP基因表达.
- 怀孕的SHRs表现出血VP降低,血压正常化,心动减速,心率变化增加 (HRV) 和增强的巴罗反射灵敏度 (BRS).
结论:
- 尽管血压正常化,但孕妇SHR显示心血管脆弱性,通过增强的交感心脏刺激和阴道招募来表明.
- 减少SON VP表达和增加V1bR表达与孕妇SHR的心血管自主控制改变相关.
- 这项研究强调了血管压素系统与高血压妊娠期间自主适应之间的复杂相互作用.
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