系统性红血性狼患者的妊娠结果和风险因素分析
Jing Lu1,2, Dan Xu1,2, Qianqian Wan3
1Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
BMC pregnancy and childbirth
|July 22, 2024
概括
在怀孕早期,活跃的全身性红斑狼 (SLE) 是对母亲和婴儿不良妊娠结果的重要预测因素. 密切监测和密集管理对于SLE患者在整个妊娠期间至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 怀孕期间的全身性红斑狼 (SLE) 管理存在重大挑战.
- 早期识别SLE患者不良妊娠结果的预测因素对于改善预后至关重要.
- 这项研究旨在确定早期怀孕的临床和实验室变量,预测SLE患者的孕产妇和新生儿并发症.
研究的目的:
- 探索怀孕早期的临床和实验室变量,预测SLE患者新生儿和母亲的不良结果.
- 促进患有SLE的孕妇的风险分层和管理策略.
主要方法:
- 对126名怀孕妇女的回顾性分析,这些妇女在怀孕第一季度被诊断出SLE.
- 对临床记录,实验室结果和怀孕结果的审查,直到怀孕12周.
- 统计分析以将早期怀孕特征与新生儿和母亲的不良结果联系起来.
主要成果:
- 怀孕早期的疾病活动被确定为新生儿不良结果 (OR=7.053) 和母亲结果 (OR=2.553) 的独立预测因素.
- 与新生儿不良结果相关的其他因素包括狼性炎,抗SSB阳性和低补充血.
- 与母亲不良结果相关的因素包括意外怀孕,新发性SLE和狼性炎.
结论:
- 怀孕早期的激活性SLE疾病与不良妊娠结果密切相关.
- 孕妇患有SLE和不良结果的危险因素需要密集管理和监测.
- 对于患有活跃疾病的患者,建议提供有关继续或终止怀孕的知情咨询.
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