肠道微生物群和具有特异性矮身儿童的代谢变化
Luyan Yan1, Bin Ye2, Min Yang3
1Department of Pediatric Endocrinology and Genetic Metabolism, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
BMC pediatrics
|July 22, 2024
概括
儿童的异常矮身 (ISS) 可能与肠道微生物组和代谢物变化有关. 确定了特定的便代谢物和细菌菌株,为ISS发展提供了新的见解.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 儿科内分泌学 儿科内分泌学
背景情况:
- 异常性矮身 (ISS) 被定义为具有未知的病因的矮身.
- 以前的研究表明,ISS儿童的肠道微生物群发生变化,便短链脂肪酸减少.
- 肠道微生物组及其代谢物在ISS病原发生中的确切作用尚不清楚.
研究的目的:
- 与正常身高对照相比,研究ISS儿童的便代谢概况和肠道微生物组合.
- 探索高度标准偏差 (SD),肠道微生物群和便代谢物之间的相关性.
- 为国际空间站确定潜在的微生物和代谢生物标志物.
主要方法:
- 招募51名中国受试者 (26名国际空间站儿童,25名对照).
- 非定向的便代谢学和中枪元基因组测序.
- 调解分析以评估身高SD,微生物组和代谢物之间的关系.
主要成果:
- 在ISS儿童中观察到便代谢物成分的显著差异,包括酸的增加和精子胺,腺和L-5-Hydroxytryptophan的减少.
- 特定的细菌菌株与不同的代谢概况有关.
- 调解分析显示了50个联系,KEGG途径分析表明营养障碍. 13个特征精确区分了国际空间站儿童的特征 (AUC=0.933).
结论:
- 肠道微生物群和微生物衍生的代谢物似乎在儿童的生长中发挥作用.
- 这些发现为了解ISS背后的机制提供了新的研究途径.
- 已识别的微生物和代谢特征可以作为国际空间站的潜在诊断指标.
相关概念视频
Anatomy of the Intestines
71.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.7K
Nature and Nurture
20.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.4K
Irritable Bowel Syndrome I: Introduction
264
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
264
Bacterial Flora of the Large Intestine
411
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
411
Signs of Puberty
303
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
303
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331


