在土著人民中使用内分泌疗法治疗癌症:系统性审查和元分析
Habtamu Mellie Bizuayehu1, Sewunet Admasu Belachew2, Shafkat Jahan3
1First Nations Cancer and Wellbeing Research Program, School of Public Health, The University of Queensland, Brisbane, Australia. h.bizuayehu@uq.edu.au.
BMC cancer
|July 22, 2024
概括
本土癌症患者显示较低的内分泌治疗 (ET) 使用,影响结果. 解决癌症护理准入方面的不平等问题对于改善全球土著人口中ET使用情况至关重要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 医疗保健服务研究 医疗服务研究
背景情况:
- 在全球范围内,土著人民在癌症发病率方面面临着差异.
- 潜在的原因可能涉及内分泌治疗 (ET) 的差异或不充分使用.
- 以前的研究往往集中在次国家层面,限制了统计能力.
研究的目的:
- 系统地审查和分析有关在土著癌症患者中使用ET的全球研究.
- 为了确定影响ET使用在这个人群中的因素.
- 提供超越次国家分析的全球视角.
主要方法:
- 系统审查和十三篇文章的元分析.
- 在主要数据库 (PubMed,Scopus,CINAHL,Web of Science,Embase) 进行的搜索.
- 采用了随机效应元分析,子组分析和元回归.
主要成果:
- 在土著人口中,ET的使用率为67%.
- 采用较大的样本大小 (≥500) 的研究显示,土著 (62%) 与非土著 (76%) 的人口中ET使用率降低了14%.
- 当地患者经常出现晚期癌症,年龄较小,获得医疗保健的机会有限,社会经济地位较低,并有更多的并发症.
结论:
- 与非土著同行相比,土著癌症患者的ET利用率较低.
- 差距很可能源于癌症治疗服务的不平等获得.
- 建议加强文化上适当的癌症护理和治疗机会,以改善ET利用率.
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