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晚发性败血症和肺炎的早产儿的肠道微生物群:一个试点病例控制研究

Ye Ma¹, Xiaoming Peng¹, Juan Zhang²

¹Department of Neonatology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), 86 Ziyuan Road, Yuhua District, Changsha, China.

BMC microbiology

|July 22, 2024

概括

肠道微生物群的改变与新生儿晚发性败血症 (LOS) 和肺炎有关. 升高的Escherichia/Shigella可能预测早产婴儿的LOS风险.

科学领域:

新生儿传染病新生儿传染病
肠道微生物组研究研究
婴儿中的微生物生态学

背景情况:

晚发性败血症 (LOS) 和肺炎对新生儿构成重大风险.
了解肠道微生物群的差异对于早产婴儿至关重要.

研究的目的:

与满期婴儿相比,研究LOS或肺炎的早产婴儿的肠道微生物群变异.
确定肠道病原体殖民化和LOS之间的相关性.

主要方法:

一个单一中心的病例控制研究.
利用16S rRNA基因测序来分析肠道微生物群.
在LOS,肺炎和对照组中比较微生物群组成.

主要成果:

肠道微生物群的多样性在LOS和肺炎组相比对照组较低.
阿克尔曼西亚,埃舍里希亚/西格拉和菌的数量增加;在疾病组中,细菌类和菌类的数量减少.
埃舍里基亚/西格拉菌的丰度增加与LOS风险相关 (AUC=0.773).

结论:

肠道微生物群失调与增加的LOS和肺炎风险有关.
在LOS婴儿中占主导地位的肠道细菌与致病原体保持一致.
升高的Escherichia/Shigella可能预测早产婴儿的LOS发作.

关键词:

诊断生物标志物诊断生物标志物肠道肠道肠道晚期发作的败血症晚期发作的败血症新生儿的微生物组一个早产的婴儿.

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