粘膜相关的不变T细胞的致病性和促炎能力增加,这些T细胞参与了口腔状平
Siting Chen1, Xiaoli Wu1, Yinshen Yang1
1Departments of Oral Medicine, Stomatological Hospital, School of Stomatology, Southern Medical University NO.366, Jiangnan Road, Guangzhou, Guangdong Province, 510280, P.R. China.
BMC oral health
|July 22, 2024
概括
粘膜关联的不变T细胞 (MAIT) 参与口腔平坦 (OLP) 病原发生. 侵蚀性OLP显示激活的MAIT细胞具有改变的表型和增加的促炎细胞因子,而皮质类固醇治疗影响MAIT细胞概况.
科学领域:
- 免疫学 免疫学 免疫学
- 口腔医学是指口腔医学.
- 自免疫性疾病 自免疫性疾病
背景情况:
- 粘膜关联不变T细胞 (MAIT) 在自身免疫性炎症性疾病中起作用.
- 它们在口腔平坦 (OLP) 病理学中的参与尚未得到充分了解.
- 这项研究研究了不同临床形式的OLP中MAIT细胞的变异.
研究的目的:
- 在不同临床类型的OLP中探索MAIT细胞的变化.
- 评估皮质类固醇治疗对OLP患者MAIT细胞的影响.
主要方法:
- 流细胞测量用于分析MAIT细胞频率,表型和OLP患者和健康对照组的功能.
- 测量了表面蛋白质的表达 (CD4,CD8,CD69,CD103,CD38,HLA-DR,Tim-3,PD-1) 和细胞因子的产生 (GzB,IFN-γ,TNF-α,IL-17A,IL-22).这些蛋白质的表达也被测量了.
- 在接受或不接受皮质类固醇治疗的OLP患者中检查了MAIT细胞.
主要成果:
- 非侵蚀性OLP显示激活CD69+CD38+MAIT细胞的频率增加.
- 侵蚀性OLP表现出MAIT细胞激活和枯竭表现型,CD69,CD103和PD-1表达量增加.
- 侵蚀性OLP患者通过MAIT细胞增加了GzB,IFN-γ和IL-17A的产生.
- 在OLP患者中,皮质类固醇治疗与CD103+MAIT细胞和GzB分泌量降低,CD8+MAIT细胞增加有关.
结论:
- MAIT细胞有助于OLP的致病性和炎症.
- 皮质类固醇治疗改变了OLP患者外周血液中的MAIT细胞表型和功能.
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