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糖尿病前期和结核病治疗结果:一个元分析
1General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
糖尿病前期增加了结核病患者不良治疗结果的风险. 然而,糖尿病前期并没有显著增加这个患者群体因任何原因死亡的风险.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 糖尿病与结核病 (TB) 风险增加和患者预后较差有关.
- 糖尿病前期对结核病治疗结果的影响尚不清楚.
研究的目的:
- 评估糖尿病前期对被诊断患有结核病的患者治疗结果的影响.
- 通过元分析综合现有队列研究的证据.
主要方法:
- 对Medline,Embase和Web of Science数据库进行了系统的搜索,以确定相关的潜在队列研究.
- 采用随机效应模型来汇集数据,并最大限度地减少研究之间的异质性.
- 八项包括3001名结核病患者的研究被纳入了元分析.
主要成果:
- 与正常血糖患者相比,糖尿病前期患者的不良治疗结果发生率明显高 (风险比[RR]:1.41,95%信心区间[CI]:1.021.96,p=0.04).
- 亚组分析表明,国家,诊断类型,年龄,随访持续时间或研究质量对这些结果没有显著的影响.
- 在随访期间,糖尿病前期并没有与全因死亡风险增加有关 (RR:1.59,95% CI:0.753.38,p=0.23).
结论:
- 前糖尿病与结核病患者不良治疗结果的风险增加有关.
- 可能需要进一步的研究来探索连接糖尿病前期和结核病治疗成功的机制.
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