针对癌症免疫治疗的红色素原生细胞
Su-Ran Li1, Zhi-Zhong Wu1, Hai-Jun Yu2
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, P. R. China.
International journal of cancer
|July 23, 2024
概括
红色素原生细胞 (EPCs) 抑制免疫系统,阻碍癌症免疫治疗. 针对这些免疫抑制EPC提供了一种新的策略,以提高患者对癌症治疗的反应率.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 免疫疗法,特别是免疫检查点封锁,已经彻底改变了癌症治疗.
- 目前对免疫治疗的反应率需要改进患者敏感化策略.
- 红状腺原生细胞 (EPCs) 是新发现的免疫抑制细胞,它们在很大程度上仍未被向.
研究的目的:
- 总结红色素原生细胞 (EPC) 的免疫调节机制,重点关注CD45+ EPC.
- 提出EPC免疫的概念,并审查针对EPC的当前战略.
- 讨论EPC向癌症治疗的挑战,并探索组合治疗的潜力.
主要方法:
- 文献综述总结了关于EPC免疫调节功能的现有研究.
- 分析瘤微环境中的EPC相互作用.
- 讨论针对EPC的当前和潜在的治疗策略.
主要成果:
- EPCs,特别是CD45+ EPCs,具有强大的免疫抑制功能.
- EPCs显著影响瘤的微环境.
- 现有的癌症治疗对EPC有不同的影响,这表明了组合治疗的潜力.
结论:
- 针对EPCs是一个有希望的新途径,可以提高癌症免疫疗法的疗效.
- 对EPC免疫和临床策略的进一步研究对于治疗进步至关重要.
- 了解当前治疗对EPC的影响是开发有效组合疗法的关键.
相关概念视频
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Tumor Immunotherapy
501
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
501
Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K


