Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Surface Membrane Barriers01:18

Surface Membrane Barriers

1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Engineering in vitro models to replicate the complexity of chronic wounds.

Nature communications·2026
Same author

Analysis of a Novel T1-like Phage KanT1 Reveals a Standalone SH3 Domain as a Widespread Component of <i>Drexlerviridae</i> Cell Lysis Module.

International journal of molecular sciences·2026
Same author

Nano-enabled enzyme-assisted layer-by-layer coating prevents biofilm formation on urinary catheters.

Acta biomaterialia·2026
Same author

Harnessing the Antimicrobial Potential of Baicalein-Coated Fe<sub>3</sub>O<sub>4</sub>/Ag Nanoparticles for Biomedical and Environmental Applications.

ACS applied materials & interfaces·2026
Same author

Bioinspired scaffold design using a custom Voronoi path generator for extrusion-based 3D printing.

Biomaterials science·2026
Same author

Editorial for the ESB 2025 collection.

Biomaterials science·2026

相关实验视频

Updated: Jun 20, 2025

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
11:19

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

10.2K

在尿管导管上采用酶式构建的纳米启用抗菌涂层.

Antonio Puertas-Segura1, Angela Gala Morena1, Silvia Pérez Rafael1

  • 1Grup de Biotecnologia Molecular i Industrial, Department of Chemical Engineering, Universitat Politècnica de Catalunya, Rambla Sant Nebridi 22, 08222 Terrassa, Spain.

ACS applied materials & interfaces
|July 23, 2024
PubMed
概括

这项研究提出了一种新的,无抗生素的涂层,用于尿导管使用银-素纳米粒子和zwitterions. 创新的涂层有效地防止细菌生物膜的形成,并保持超过一周的功能.

关键词:
防腐污染 防腐污染的方法抗微生物药物是一种抗菌药物.卡尔博克西贝他因 (Carboxybetaine) 是一种拉卡斯拉卡斯拉卡斯拉卡斯拉卡斯拉银-亚麻纳米颗粒的使用.尿导管是用于尿道的.

更多相关视频

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.0K
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

9.1K

相关实验视频

Last Updated: Jun 20, 2025

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
11:19

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

10.2K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

22.0K
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
10:43

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

9.1K

科学领域:

  • 生物材料科学 生物材料科学
  • 传染病研究 传染病研究
  • 纳米技术纳米技术

背景情况:

  • 导管相关的尿路感染 (CAUTIs) 是医院获得感染的重要原因,导致医疗保健成本增加和长时间住院.
  • 目前的CAUTI预防策略通常依赖于银合金涂层,其有效性有限,并引发了对抗菌素耐药性的担忧.
  • 对于尿导管的新型,有效和安全的抗微生物涂层有着迫切的需要.

研究的目的:

  • 开发和评估一种新的无抗生素复合涂层,用于尿道导管,具有杀菌和防腐性质.
  • 为了增强导管的性能,将银化素纳米颗粒与多 () () 结合起来.
  • 评估涂层在防止生物膜形成,降低细菌活力和确保生物相容性的有效性.

主要方法:

  • 复合涂层的制造方法是通过在现场接种银化素纳米颗粒和使用laccase. carboxybetaine) 的聚乙烯 (poly ((carboxybetaine) zwitterions) 的基质聚合.
  • 通过测量非特异性蛋白质吸附,评估涂层的防性质.
  • 在水力动力流条件下评估涂层对细菌的杀菌功效.
  • 在体外和体内测试涂层功能和生物相容性在一周的时间内使用动物模型.

主要成果:

  • 开发的复合涂层证明有效地预防非特异性蛋白质吸附.
  • 在水力动力流下,导管表面的细菌活力减少了超过2个日志.
  • 涂层的抗微生物和抗污染功能在体外和体外环境下持续超过一周.
  • 动物模型表现出极好的生物相容性,没有明显的细胞毒性迹象.

结论:

  • 这种新型的无抗生素复合涂层通过提供强大的杀菌和抗污染特性,有效地对抗导管相关的尿路感染.
  • 现场制造方法利用素化学和乳酸,为开发先进的医疗器械涂层提供了一种多功能方法.
  • 这项技术在减少CAUTI的发生率,改善患者的治疗结果和降低与医疗保健相关的财务负担方面具有显著的前景.