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细胞外囊泡的产生:宿主和候选菌之间的相互作用中的双向效应

Kamila Kulig¹, Maria Rapala-Kozik¹, Justyna Karkowska-Kuleta¹

¹Department of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland.

Current research in microbial sciences

|July 23, 2024

概括

细胞外囊泡 (EVs) 在Candida真菌和宿主细胞之间进行沟通. 菌EVs促进感染,而宿主EVs可以抑制Candida生长并增强免疫细胞功能.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

坎迪达真菌使用毒性因子来感染宿主,而宿主细胞使用防御机制.
细胞外囊泡 (EVs) 是宿主-病原体相互作用的关键媒介,由Candida和宿主细胞产生.
了解EVs在Candida感染中的作用对于开发新的治疗策略至关重要.

研究的目的:

审查当前对宿主EVs的知识,以应对Candida感染.
研究真菌EVs对宿主细胞功能的影响.
为了阐明宿主和Candida EVs之间的相互通信.

主要方法:

对涉及EVs的宿主-病原体相互作用研究的文献综述.
对Candida EVs对宿主细胞的影响的研究分析,包括粘附和细胞因子调节.
检查宿主细胞EVs对Candida活力和免疫细胞活性的影响.

主要成果:

菌类EV增强Candida对宿主细胞的粘附 (例如,C. auris) 并调节细胞因子的产生 (IL-6,IL-8,IL-10,IL-12p40,TGF-β,TNF-α),促进感染.
来自宿主细胞的EVs可以抑制Candida的增殖和生存能力.
主体EV可以增强效应细胞的候选杀菌活性.

结论:

电子细胞在Candida和宿主细胞之间的动态相互作用中发挥着重要作用.
在感染期间,EVs的互交交换有助于细胞信号传输和跨王国通信.
针对EV介导的通信是控制Candida感染的潜在途径.

关键词:

这是一种Candida Candida.表面上皮质 (epithelium) 是一个层次的表皮.细胞外囊泡中的细胞外囊泡.菌的真菌是一种主机的响应主机的响应炎症炎症是一种炎症.巨细胞是一个巨细胞.

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