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Updated: May 12, 2026

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固体瘤中的内高内皮静脉:一个聚合性研究

Bin Wang¹, Yin Han², Jie Liu¹

¹Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in immunology

|July 23, 2024

概括

与瘤相关的高内皮静脉 (TA-HEVs) 的阳性与较好的整体存活率和固体瘤中无病存活率有关. 这一元分析强调TA-HEVs作为预后预测的潜在免疫生物标志物.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

与瘤相关的高内皮静脉 (TA-HEVs) 在瘤微环境中越来越多地被识别出来.
它们在各种固体瘤中的预后意义尚未全面阐明.

研究的目的:

进行综合分析,探索TA-HEVs在固体瘤中的预后价值.
调查TA-HEV状态与临床病理特征之间的关联.

主要方法:

我们对PubMed,科学网,Embase和Cochrane图书馆进行了系统的搜索.
对13项回顾性队列研究 (1,933名患者) 的元分析,使用危险比率 (HR) 和几率比率 (OR).
进行了子组,敏感性和出版偏差分析.

主要成果:

TA-HEV阳性与改善的整体存活率 (OS) 和无病存活率 (DFS) 相关联.
没有发现与无进展生存 (PFS) 或癌症特异性生存 (CSS) 有意义的关联.
TA-HEV与淋巴结和远程转移相反相关,但与较差的瘤分化有关.

结论:

这一元分析是第一个全面评估TA-HEVs在固体瘤中的预后价值的元分析.
TA-HEV与预后和临床病理特征有显著的相关性.
TA-HEVs可以作为新的免疫相关生物标志物用于临床评估和预后预测.

关键词:

临床病理学参数临床病理学参数高内皮膜静脉的高内皮膜静脉.免疫疗法免疫疗法预后预后预后固体瘤是一个固体瘤.

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