儿童创伤作为自闭症特征和抑郁症之间的调解者:来自ALSPAC出生队列的证据
Jack F G Underwood1,2, Paul Madley-Dowd2,3,4, Christina Dardani2,3
1Neuroscience and Mental Health Innovation Institute, Cardiff University, United Kingdom.
medRxiv : the preprint server for health sciences
|July 23, 2024
概括
自闭症和自闭症特征增加了儿童创伤和成人抑郁症的风险. 童年创伤加剧了自闭症特征的个体的抑郁症,突出了一个关键的联系.
科学领域:
- 神经发育障碍 神经发育障碍
- 精神病学是一个精神病学.
- 发展心理学是发展心理学.
背景情况:
- 自闭症和自闭症特征与更高的儿童创伤和成人精神病理的风险有关.
- 童年创伤在成年人中自闭症-抑郁症关系中的具体作用仍然不清楚.
研究的目的:
- 研究童年创伤对自闭症,自闭症特征和成人抑郁症之间的关联的影响.
- 分析自闭症和创伤暴露与儿童到成年人之间的抑郁症症状轨迹.
主要方法:
- 使用了英国出生队列 (N=9,659) 与从出生到28岁的前性数据.
- 采用混合效应的生长曲线模型来评估抑郁的轨迹.
- 进行了后勤回归和调解分析,以检查自闭症,创伤和抑郁症的关联.
主要成果:
- 自闭症变量显示,从10-28岁,抑郁症症状轨迹增加.
- 社交沟通困难 (SCD) 与成人抑郁症有很强的联系 (OR=2.15).
- 童年创伤和自闭症特征协同增加了抑郁症得分,有证据表明直接和创伤介导的途径.
结论:
- 自闭症/自闭症特征增加了童年创伤和成人抑郁症的可能性.
- 从童年开始的抑郁症症状轨迹持续到成年.
- SCD和童年创伤对抑郁的综合影响大于单个因素.
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