评估生活方式因素与不同炎症状态下的脚骨矿物质密度之间的关联
Ruoyang Feng1, Shiqiang Cheng2, Feng Zhang2
1Department of Joint Surgery, HongHui Hospital, Xi'an Jiao Tong University, Xi'an, Shanxi, 710054, China.
Heliyon
|July 23, 2024
概括
维生素D的摄入有益于骨矿物质密度 (BMD),而酒精和吸烟会损害它. 咖啡可能会在高度炎症状态下保护部骨质瘤,这表明生活方式会根据炎症不同影响骨健康.
科学领域:
- 骨健康和新陈代谢
- 炎症和免疫力 炎症和免疫力
- 营养科学 营养科学
背景情况:
- 骨矿物质密度 (BMD) 对于骨健康至关重要,并且在炎症状态期间,其通过生活方式因素的调节仍然不清楚.
- 炎症可以显著影响全身健康,可能会影响骨代谢和骨密度.
研究的目的:
- 为了研究咖啡消费,维生素D (VD) 摄入,吸烟和酒精消费与不同炎症状态的成年人脚骨质疏松症之间的联系.
- 为了确定生活方式因素是否与炎症标志物相互作用,从而影响骨矿物质密度.
主要方法:
- 来自249,825名英国生物库参与者的表型数据的分析.
- 使用C反应蛋白 (CRP) 水平和全身免疫炎症指数评估的炎症状态.
- 线性回归模型用于检查生活方式因素和脚BMD之间的关联和相互作用.
主要成果:
- 维生素D摄入量与部 BMD 有积极的关联 (P < 0.001).
- 酒精消费和吸烟与部BMD有负面关联.
- 在低炎症状态下,咖啡消费与部骨质瘤有负面关联,但在高炎症状态下没有显著关联.
结论:
- 维生素D的摄入对成人部骨质疏松有好处,而酒精和吸烟是有害的.
- 咖啡可以作为一种保护剂,防止炎症诱导的骨质损失在高炎症状态的成年人.
- 生活方式因素与炎症状态具有复杂的相互作用,对骨矿物质密度产生差异性影响.
相关概念视频
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:25Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
01:17Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
01:40Bone Remodeling
38.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.2K
01:31Essential Minerals for Bone Health
3.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.9K