在阳性结核病 lipoarabinomannan 结果后开始治疗低结核病
Tinne Gils1,2, Thandanani Madonsela3, Mashaete Kamele4
1Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
ERJ open research
|July 23, 2024
概括
一个阳性尿液TB-LAM测试应该促使结核病治疗. 然而,当TB-LAM阳性但Xpert阴性时,治疗接受率较低,可能是由于临床医生不信任和错误阳性.
科学领域:
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
- 公共卫生 公共卫生
背景情况:
- 结核病仍然是一个全球卫生挑战.
- 快速诊断对于及时启动治疗至关重要.
- 尿结核病-LAM是一种有前途的结核病诊断点治疗测试.
研究的目的:
- 评估尿结核病-LAM结果对结核病治疗启动的影响.
- 为了调查影响在不一致的测试结果后接受治疗的因素.
主要方法:
- 对患者数据的回顾性分析.
- 对TB-LAM和Xpert MTB/RIF测试结果进行比较.
- 对结核病治疗开始率的评估.
主要成果:
- 建议在开始结核病治疗时进行尿液TB-LAM阳性结果.
- 结核病治疗吸收率较低,在结核病-LAM测试呈阳性,再加上Xpert测试呈阴性后观察到.
- 潜在的促成因素包括临床医生对TB-LAM的不信任以及虚假阳性结果的发生.
结论:
- TB-LAM和Xpert之间的不一致的结果需要仔细的临床考虑.
- 建立临床医生对TB-LAM准确性的信心对于有效的结核病控制策略至关重要.
- 需要进一步的研究来解决假阳性TB-LAM结果的问题.
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