唾液中酸盐/酸盐总量与支气管切开症的恶化和Pseudomonas aeruginosa殖民有关
Yaya Zhou1,2, Xinliang He1,2, Jian Tang1
1Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
ERJ open research
|July 23, 2024
概括
唾液中酸盐/酸盐的含量表明支气管切除症的严重程度,并预测疾病的恶化. 较高的水平与Pseudomonas aeruginosa感染和较差的肺功能相关.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 微生物学 微生物学
- 生物标志物发现发现
背景情况:
- 反应性物种,包括唾液酸盐/酸盐,都与支气管炎有关.
- 唾液酸盐/酸盐是疾病严重程度和进展的潜在生物标志物.
研究的目的:
- 为了研究液中酸盐/酸盐水平与支气管切开症的恶化之间的关联.
- 探索唾液中酸盐/酸盐和气道微生物群组成之间的关系.
主要方法:
- 来自85名稳定支气管切除症患者的唾液样本被分析为总酸盐/酸盐.
- 使用16S核糖体RNA测序和PICRUSt来描述气道微生物群并预测脱.
- 研究了与疾病严重程度得分 (E-FACED,BSI),恶化,症状和P. aeruginosa殖民的关联.
主要成果:
- 唾液中酸盐/酸盐的增加与支气管切除症的严重程度增加 (E-FACED,BSI) 和之前的恶化相关.
- 较高的酸盐/亚酸盐水平与更糟糕的咳,唾液和呼吸障碍得分有关.
- S. aeruginosa殖民与较高的酸盐/酸盐水平和丰富的脱路径有关.
- 唾液酸盐/酸盐预测了一年恶化 (AUC 0.741).
结论:
- 唾液酸盐/酸盐作为一个有价值的生物标志物用于支气管切除症的严重程度.
- 酸盐/亚酸盐水平与Pseudomonas aeruginosa在支气管切除症患者的殖民化有关.
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