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支气管切除风险增加和炎症性肠道疾病的相关风险因素:10年韩国全国队列研究
Jun Su Lee1,2, Bumhee Yang3,2, Hye Soon Shin4
1Division of Gastroenterology, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
炎症性肠病 (IBD) 增加了发展支气管病的风险,特别是在性结肠炎患者中. 这种并发症显著提高IBD个体的疾病负担.
科学领域:
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 和支气管切除风险之间的关系尚未得到充分理解.
- 目前尚不清楚支气管切除症是否会加剧IBD患者的疾病负担.
研究的目的:
- 为了确定IBD是否会增加支气管切除症的发生率.
- 为了比较克罗恩病 (CD) 和性结肠炎 (UC) 之间的支气管切除风险.
- 为了确定IBD患者支气管切除症的风险因素,并评估对疾病负担的影响.
主要方法:
- 进行了基于人口的匹配队列研究.
- 从韩国国家医疗保险服务-全国样本队列 (2002-2012) 分析了20岁及以上IBD成年人的数据.
主要成果:
- IBD患者患上支气管切除症的风险增加了21% (aHR 1.21).
- 性结肠炎,但不是克罗恩病,与支气管切除风险的增加显著相关 (aHR 1.42).
- 关键的危险因素包括年龄,男性性别,医疗援助,体重不足,COPD和糖尿病. 患有IBD和支气管切除症的患者经历了更高的死亡率,急诊和住院率.
结论:
- 炎症性肠病与支气管切除症的风险增加有关.
- 支气管切除导致IBD患者的疾病负担显著增加.
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