沙力克斯 (Salix Mucronata) 的抗精神病潜力在胺诱导的老鼠身上
Ntombifuthi P Ngubane1, Musa V Mabandla2, Brenda Z De Gama1
1Discipline of Clinical Anatomy School of Laboratory Medicine and Medical Sciences College of Health Sciences University of KwaZulu-Natal Westville Campus, Private Bag X54001, Durban 4000, South Africa.
IBRO neuroscience reports
|July 23, 2024
概括
这项研究表明,南非植物Salix mucronata在老鼠中逆转了胺诱导的社会缺陷,类似于抗精神病药物RISPERIDONE. 这些发现表明,S. mucronata有可能成为治疗精神分裂症症状的自然疗法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 民族植物学 民族植物学
背景情况:
- 精神分裂症是一种复杂的精神障碍.
- 传统医学提供潜在的治疗化合物.
- Salix mucronata 在南非用于治疗心理健康状况.
研究的目的:
- 为了研究 Salix mucronata 提取物的抗精神病潜力.
- 评估胺对大鼠社会行为和动机的影响.
- 为了确定Salix mucronata或risperidone是否可以逆转胺诱导的损伤.
主要方法:
- 成年雄性斯普拉格·道利大鼠被给予胺 (30毫克/公斤) 持续5天.
- 治疗组接受了RISPERIDONE (6毫克/公斤) 或Salix mucronata提取物 (5毫克/公斤) 在7天内.
- 评估了社会互动,新奇性,无情感,以及大脑质量/体积.
主要成果:
- 胺诱发了社会退缩和减少了新奇性,这些都是Salix mucronata和risperidone扭转的.
- 这两种治疗都增加了多巴胺和乙胆水平.
- 在接受胺治疗的组中观察到大脑体积减少.
结论:
- Salix mucronata 呈现出与瑞斯佩里可比的抗精神病性质.
- 这些发现支持Salix mucronata用于精神分裂症的以太植物学用途.
- 进一步研究 Salix mucronata 作为治疗剂是有必要的.
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