通过ART怀孕的单子喘风险:一个回顾性队列研究
Shuangying Liu1,2,3, Xiaoqian Zhou1, Wei Wang1,2,3
1Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Human reproduction open
|July 23, 2024
概括
通过辅助生殖技术 (ART) 怀孕的孩子与自然怀孕的孩子相比,患儿喘的风险类似. 哺乳可能有助于降低ART怀孕婴儿的喘风险,特别是那些新生儿重症监护室入院的婴儿.
科学领域:
- 生殖医学和围产期健康
- 儿科过敏和免疫学
背景情况:
- 关于辅助生殖技术 (ART) 是否增加后代喘风险的现有证据是不一致的.
- 之前的研究受限于种族,地理分布,不充分的混调整和特定的ART方法.
- 产科和新生儿结局对ART-喘关联的调解效应仍然不清楚.
研究的目的:
- 为了确定通过ART怀孕的单独胎儿是否比自然怀孕 (NC) 单独胎儿有更高的喘风险.
- 调查新生儿结局对ART和儿童喘之间的关联的调解效应.
主要方法:
- 追溯性,单中心观察性研究,涉及3227名ART受孕者和1206名年龄在3-6岁之间的NC单身动物.
- 根据医生诊断定义的喘或过去12个月的喘息.
- 多变量逻辑回归和纵向调度结构方程建模被用于分析,调整多个混因素.
主要成果:
- 在调整 (aOR,0.66 [95% CI,0.44-1.03];P=0.126) 后,在ART单独受孕 (5.2%) 和NC单独受孕 (4.2%) 之间,儿童喘的总体风险相似.
- 在各种ART方法 (IVF,ICSI,新鲜或冷胚胎移植) 中没有观察到喘风险的显著差异.
- 新生儿重症监护室 (NICU) 的入院显示出显著的积极间接影响,而母乳养显示出对ART-喘关联的负面间接影响.
结论:
- 接受人工智能治疗的单身婴儿与NC单身婴儿有类似的喘风险,这使得接受人工智能治疗的不孕夫妇感到放心.
- 建议母乳养作为一种潜在的干预措施,以减轻ART受孕儿童的喘风险,特别是那些入院于NICU的儿童.
- 由于研究的回顾性,单中心性质和探索性调解分析,研究结果应谨慎解释.
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