在歌鸟RA和HVC的神经群体动态在学习的运动声声行为期间
Pablo Tostado-Marcos1,2,3, Ezequiel M Arneodo3, Lauren Ostrowski4
1Department of Bioengineering.
ArXiv
|July 23, 2024
概括
研究人员研究了歌鸟的神经群体动态.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 动物行为 动物行为
背景情况:
- 学习的运动行为需要跨大脑区域的复杂神经协调.
- 了解运动通路中的人口级神经动力学是至关重要的,但有限.
- 唱歌的鸟提供了一个模型系统来研究学习的声乐生产.
研究的目的:
- 在歌鸟学习声乐生产期间,研究HVC (正确) 和RA区域的神经群体动态.
- 描述歌唱行为背后的神经多元体的结构和动态.
- 为了比较不同运动通路区域中神经活动和语音输出之间的关系.
主要方法:
- 在醒着唱歌的歌鸟中使用Neuropixels探针同时记录HVC和RA中神经元群的细胞外记录.
- 使用状态空间模型分析神经群体动态,以识别低维多元体和轨迹.
- 解码模型被用来从神经活动和潜伏中重建语音输出.
主要成果:
- 在HVC和RA中,神经活动在唱歌期间组织在低维的多元体上,其轨迹有时结构.
- 在HVC和RA的潜在轨迹预测声序过渡,但RA显示了与声输出的更连续的关系.
- 从HVC和RA神经潜质进行高保真声输出重建是可能的;基于潜质的解码一般化到新的神经元子群体.
结论:
- 在HVC和RA中神经群体动态表现出不同的时间结构,但共享用于声动控制的保存的低维分组.
- 来自人口活动的神经潜伏,提供了一个强大的代表解码复杂的运动行为,如唱歌.
- 这些发现表明,在这些歌鸟大脑区域中,保留了限制声动运动活动的神经元组.
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