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[离散元素方法 (DEM) 在固体中医药制剂的制药过程中的应用]

Yi-Feng Wu¹, Zi-Qian Wang², Xin-Hao Wan¹

¹Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China Jiangxi Technology Innovation Center of Green Manufacturing of Chinese Medicine Nanchang 330004, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

|July 23, 2024

概括

数字模拟,特别是离散元件方法 (DEM),在药物开发中越来越多地使用. 这篇论文回顾了DEM.

科学领域:

制药科学制药科学
计算力学计算力学计算力学
传统中国医学 (TCM) 是一种

背景情况:

数字模拟,包括离散元件方法 (DEM),越来越多地应用于制药研发 (R&D).
DEM是一种强大的数值方法,用于模拟不连续的介质,在药物配方中越来越多地使用.
固体传统中医药 (TCM) 制剂具有复杂的配方过程.

研究的目的:

审查和分析DEM在固体TCM制剂的制药过程中的应用.
确定目前使用DEM用于TCM配方的研究进展和挑战.
为提高TCM制剂的高质量生产提供新的见解.

主要方法:

关于德意志德国近期进展的文献综述.
对DEM在固体TCM制备过程中的应用进行分析.
讨论在TCM中对DEM的挑战和未来方向.

主要成果:

在制药过程中,DEM已经显示出作为模拟不连续介质的有效工具的巨大潜力.
在固体TCM制备中DEM的应用正在扩大,提供新的模拟功能.
对于TCM的DEM应用的关键挑战包括数据采集和模型验证.

结论:

DEM提供了一种有价值的方法来理解和优化固体TCM准备流程.
应对当前的挑战将进一步促进高质量和高效的TCM生产.
这一审查为未来的研究提供了基础,将DEM整合到TCM制药制造中.

关键词:

离散元素方法的离散元素方法.数字模拟的数字模拟.药物制造过程中的制药过程.固体中国传统医学 (TCM) 制剂.

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