[Lonicera macranthoides和L. japonica之间的质量控制模式基于通过感应合等离子体质谱学的多元素差异]
Shi-Jun Liu1, Yang-Qian-Nan Tang1, Yu-Ai Lu1
1Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.
概括
这项研究使用了感应合等离子体质谱法 (ICP-MS) 来发现Lonicera macranthoides和Lonicera japonica之间的关键无机元素差异. ,,,和被确定为显著的差异标记物.
科学领域:
- 分析化学 分析化学
- 植物科学 植物科学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 罗尼克拉 (Lonicera macranthoides) 和罗尼克拉 (Lonicera japonica) 呈现出已知的有机物质差异.
- 关于这些Lonicera物种之间的无机元素差异的研究是有限的.
- 了解元素概况对于质量控制和药理学评估至关重要.
研究的目的:
- 使用元素代谢学来比较Lonicera macranthoides和Lonicera japonica的无机元素概况.
- 为了识别和量化两种物种之间的不同无机标记物.
- 为改善质量控制和对药物效应的理解奠定基础.
主要方法:
- 使用诱导合等离子体质谱法 (ICP-MS) 开发一种非向的元素代谢学方法.
- 基于预测中的变量重要性 (VIP),P值和折叠变化 (FC) 的差异化无机标记者的选.
- 对已识别的差异标记进行有针对性的定量分析.
主要成果:
- 基于ICP-MS的元素代谢模型有效地根据元素含量区分了L. macranthoides和L. japonica.
- 确定了四个关键的差异标记: (55) Mn, (209) Bi, (111) Cd和 (85) Rb.
- 有针对性的分析证实了L. japonica的高~209) Bi,L. macranthoides的高~55) Mn,~111) Cd和~85) Rb.
结论:
- 基于ICP-MS的非向和向元素代谢学有效地通过无机元素来区分L. macranthoides和L. japonica.
- 已识别的差异标记器提供了对药物特性潜在变化的洞察力.
- 这项研究为基于无机元素的质量控制和这些Lonicera物种的药理学研究奠定了基础.
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