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年轻人到中年人的血管风险对大脑健康的影响和值
Matthew B Maas1,2, Simin Mahinrad1, Sanaz Sedaghat1,3
1Department of Neurology (M.B.M., S.M., S. Sedaghat, P.B.G., F.A.S.), Northwestern University, Chicago, IL.
成年早期的高静脉压 (SBP) 与加速的大脑衰老和认知能力下降有关. 一个SBP的111mmHg或更低可能会保护对中年大脑健康的有害影响.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 老年学是指老年学的学科.
背景情况:
- 血管风险因素,特别是高血压,有助于加速大脑衰老.
- 了解这些因素在成年期的影响对于预防策略至关重要.
研究的目的:
- 在整个成年期量化与血管风险因素相关的风险.
- 评估对影响大脑健康的风险值的经验证据.
主要方法:
- 分析了来自CARDIA研究 (到30年) 关于血压,胆固醇,葡萄糖和BMI的纵向数据.
- 认知功能和白质超强度体积在30年被评估.
- 混合效应模型和横截面分析被用来将暴露与中年大脑健康结果联系起来.
主要成果:
- 缩血压 (SBP) 的增加与认知功能 (蒙特利尔认知评估得分) 有负面关联.
- SBP暴露与中年认知表现和白质超强度体积有显著联系.
- 确定SBP值为111 mm Hg,低于该值没有观察到有害的认知影响.
结论:
- 成年早期的SBP是影响中年认知表现和大脑结构的关键血管风险因素.
- 维持SBP在111mm Hg或以下可能是维护认知健康的关键值.
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