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Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions
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微流体延伸流装置用于研究聚合物微粒形成过程中的质量转移动态.

Suryavarshini Sundar1, Ghata Nirmal1, Suraj Borkar1

  • 1Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada. arun.ramchandran@utoronto.ca.

Soft matter
|July 23, 2024
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概括

本研究使用微流体延伸流装置模拟了聚合物微粒制造中的溶剂提取动态. 这些发现解释了随着时间的推移下降半径的变化,这对于控制药物释放动力学至关重要.

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科学领域:

  • 材料科学 材料科学 材料科学
  • 化学工程是化学工程的重要组成部分.
  • 生物医学工程 生物医学工程

背景情况:

  • 聚合物微粒是持续药物输送的关键.
  • 溶剂提取是一种常见的制造方法,但在剪切下提取动态不太清楚.
  • 提取速率对微粒物质和药物释放有重大影响.

研究的目的:

  • 开发一种用于溶剂提取动态的实验性质量转移模型.
  • 为了研究单滴水平上对提取的剪切效应.
  • 了解提取速率与微粒子特征之间的关系.

主要方法:

  • 使用微流体延伸流装置 (MEFD) 控制剪切.
  • 采用计算机控制的反算法来捕捉和观察单聚合物滴.
  • 测量了随着时间的推移,聚乳糖合糖酸 (PLGA) 在乙烯酸乙酸 (EtOAc) 中降落半径的变化,以不同的延伸速率 (0.110 s-1).

主要成果:

  • 观察到明显的短时间 (R ∼ t) 和长时间 (R = 恒定) 异位对降落半径变化.
  • 基于质量转移原理,物理解释了观察到的溶解趋势.
  • 在聚合物系统中开发了用于溶剂提取的预测运输模型.

结论:

  • 开发的模型准确地预测了提取速率和微粒子组成.
  • 了解切割依赖提取对于优化微粒制造和药物释放至关重要.
  • 这项工作促进了对乳液中的对流式质量转移的理解.