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Updated: Jun 20, 2025

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儿科年龄的子宫外库辛综合症在儿童年龄的子宫外库辛综合症
Guido Roberto1, Maria Elena Aloini1, Irene Biondo1
1Azienda Ospedaliera Sant'Andrea, Endocrinology, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
Endocrine, metabolic & immune disorders drug targets
|July 23, 2024
概括
宫外ACTH分泌的神经内分泌瘤导致库辛综合征. 68Ga-PET/DOTATOC成像和ACTH监测有效地发现并管理了一种罕见的胸膜神经内分泌瘤病例.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 核医学就是核医学.
背景情况:
- 宫外ACTH分泌导致库辛综合征是罕见的,起源于神经内分泌瘤.
- 内源性库辛综合征的发病率很低,儿童占病例的一小部分.
研究的目的:
- 描述一个充满挑战的宫外库辛综合征病例.
- 评估68Ga-PET/DOTATOC成像和ACTH水平监测在诊断和手术管理中的实用性.
主要方法:
- 一个17岁的女性患有子宫外库辛综合征的病例报告.
- 使用68Ga-PET/DOTATOC和18FDG-PET扫描来定位病变.
- 在整个手术过程中监测上腺皮质激素 (ACTH) 水平.
主要成果:
- 最初的PET扫描结果是阴性;随后的68Ga-PET/DOTATOC检查发现了一个胸膜结节.
- 尽管进行了乳腺切除术,但高皮质醇症仍然存在,这表明切除不完全.
- 重复的成像和手术成功地解决了这种情况,通过正常化的ACTH水平证实了这一点.
结论:
- 68Ga-PET/DOTATOC是识别ACTH分泌的神经内分泌病变的敏感和特定工具.
- 在手术期间监测短效ACTH水平有助于确认完整的手术切除.
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