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相关概念视频

Hormones of the Pituitary Gland01:27

Hormones of the Pituitary Gland

6.5K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
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Neurotransmitters01:31

Neurotransmitters

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Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
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Major Hormones and Their Functions01:27

Major Hormones and Their Functions

362
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
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The Pituitary Gland01:17

The Pituitary Gland

6.6K
The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
6.6K
Feedback Loops01:01

Feedback Loops

57.4K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Organization of the Brain01:30

Organization of the Brain

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The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
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相关实验视频

Updated: Jun 20, 2025

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
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Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

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大脑是否会产生益生菌素?

David R Grattan1,2

  • 1Centre for Neuroendocrinology and Department of Anatomy, University of Otago, Dunedin, New Zealand.

Journal of neuroendocrinology
|July 23, 2024
PubMed
概括
此摘要是机器生成的。

尽管它具有受体,但大脑中益生素 (PRL) 的产生不太可能.

关键词:
大脑的前乳腺素是前乳腺素.在下丘脑中,下丘脑益生菌蛋白是一种益生菌素.益生菌受体的受体是益生菌受体.

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Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
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X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models
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相关实验视频

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Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

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Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
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X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models
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科学领域:

  • 神经内分泌学神经内分泌学
  • 分子精神病学分子精神病学
  • 激素信号传递 激素信号传递

背景情况:

  • 益生菌受体 (Prlr) 在大脑中分布广泛,特别是在下丘脑.
  • 益生菌对中枢神经系统功能有已知的影响,促使人们对其大脑合成进行调查.
  • 益生菌作为大脑神经的潜力是长期以来的一个研究问题.

研究的目的:

  • 批判性地评估现有的证据,对大脑内内源性产生的益生菌素.
  • 评估大脑中合成的益乳素是否具有显著的生理相关性.

主要方法:

  • 通过使用各种抗体来检测大脑中益生素类免疫反应活性的研究的综述.
  • 在大脑组织中检测益生菌mRNA的数据的分析,通常使用敏感放大技术.
  • 考虑现代分子技术的发现,如in situ杂交和单细胞RNA测序.

主要成果:

  • 关于大脑中益生菌素产生的证据是不一致的和可变的,与成熟的Prlr分布不同.
  • 与垂体腺相比,在大脑中检测到非常低的水平的prolactin mRNA.
  • 高度敏感的检测方法带有错误阳性结果的风险;先进的技术尚未证实大脑中益生菌素的合成.

结论:

  • 根据目前的证据,大脑内源性产生益生素被认为不太可能.
  • 即使在特定条件下 (例如神经保护) 在大脑中产生益生素,其生理影响也很可能是最小的.
  • 在大脑中观察到的益生菌的效果最好地解释为来自垂体腺的益生菌进入大脑组织.