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Updated: Jun 20, 2025

Associated Chromosome Trap for Identifying Long-range DNA Interactions
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Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

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一个单一的CAA中断在含有CAG重复发针的DNA三向结处导致了平价依赖的捕获

Gillian M Cadden1, Svea J Wilken1, Steven W Magennis1

  • 1School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, UK.

Nucleic acids research
|July 23, 2024
PubMed
概括

短串重复 (STR) 的基因组扩展导致人类疾病. 在STR中断,像CAA在CAG重复中一样,显著改变DNA三向结 (3WJ) 结构和动态,可能防止疾病.

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