早期的在线时间
概括
在剖腹产时,添加美트로尼达到凯法林的预防措施并没有减少产后感染. 这项研究发现,群体之间的感染率没有显著差异,这表明目前的预防策略可能需要重新评估.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 手术预防手术预防.
背景情况:
- 剖腹产带有高风险的孕产妇和新生儿并发症,包括产后感染.
- 与怀孕相关的败血症是孕产妇死亡的一个重要原因,特别是在南非.
- 优化预防性抗生素治疗方案旨在减少剖腹产后的产后感染和败血症.
研究的目的:
- 为了比较单独使用塞法佐林与塞法佐林加上美特罗尼达在接受剖腹产的妇女中预防产后感染的疗效.
- 评估扩展谱抗生素预防对剖腹产感染率的影响.
主要方法:
- 在Kalafong省三级医院进行了一项随机对照试验.
- 接受剖腹产的患者随机分配到接受单独的塞法佐林 (控制) 或塞法佐林加上美트로尼达 (干预).
- 结果包括手术部位感染,腹腔切除术和子宫切除术的发生率.
主要成果:
- 整体手术部位感染率为5.64%,单独服用塞法佐林 (5.33%) 和服用塞法佐林加上美트로尼达 (5.96%) 组之间没有显著差异.
- 二次结果,包括腹腔切除和子宫切除率,也显示两组之间没有统计学上显著的差异.
- 这项研究表明,在剖腹产预防中,甲二醇与塞法林结合使用时,没有额外的益处.
结论:
- 在剖腹产时,添加美特罗尼达 (metronidazole) 与塞法林 (cefazolin) 进行预防,似乎没有降低产后感染率.
- 产后感染是多因素的,加强败血症护理捆绑可能涉及解决各种促成因素.
- 目前的证据不支持在剖腹产时将甲二醇常规添加到塞法林中进行预防.
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