相关实验视频
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Methods to Test Visual Attention Online
Published on: February 19, 2015
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B F Jacobson1, S Louw2, E Schapkaitz3
1National Health Laboratory Service and Department of Haematology and Molecular Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. clot@nhls.ac.za.
概括
高空飞行可以使健康人群的血液更容易凝固. 需要进一步的研究来确定血液凝块预防药物是否可以降低这种风险.
科学领域:
- 航空医学 航空医学
- 血液学 血液学 血液学
- 身体生理学 身体生理学
背景情况:
- 长途飞行将与航空相关的血栓塞 (ART) 的风险增加两到四倍.
- 以前的研究探讨了空中旅行期间缺氧,脱水和不运动如何影响血液静止.
- 这项研究专门研究了高海拔地区在ART风险中的作用.
研究的目的:
- 为了确定航空旅行期间高空暴露是否会导致高凝血状态.
- 为了评估血液静止标志物和水分状态的变化,以响应模拟高空飞行.
主要方法:
- 40名健康的志愿者在没有加压的飞机上被暴露在18000英尺的模拟高度中,持续1小时.
- 补充氧气时,氧和度保持在92%以上.
- 在飞行前和飞行后采集了血液和尿液样本,以测量D-二聚合物,血栓弹性扫描 (TEG) 参数,·威莱布兰德因子 (VWF) 活性和尿液度.
主要成果:
- 在飞行后的D-二元水平,VWF活性,尿液度和TEG参数 (R时间,K时间,MA) 中观察到显著的变化 (p<0.001).
- 尿液度与VWF活性呈正相关性 (r=0.469;p<0.002).
结论:
- 高海拔的航空旅行会在健康个体中诱导高凝血状态.
- 建议进行进一步的研究,以评估血栓预防在缓解高空飞行期间凝血激活的有效性.
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